Wednesday, 4th November ESA-SRB-NZSE-CaSR 2026 in conjunction with ENSA

Closed meeting, invitation only. Organiser Office, Ground Floor ICC

• How blue sky research led to a natural product for glucose support   - Alexander Tups
• Turning Testosterone Against Prostate Cancer: Investigating Bipolar Androgen Therapy as an Emerging Treatment - Mitchell Lawrence
• CREBRF: Uncoupling obesity from type 2 diabetes - Rinki Murphy
• Beyond Bone Density: Novel imaging of bone microarchitecture, strength and joint health - Ayse Zengin

• Living with hypoparathyroidism and working together to overcome it - Roderick Clifton-Bligh, Patty Keating, Michele Rayes and Nicholas Love
• Calcilytics for the Treatment of Individuals with Autosomal Dominant Hypocalcemia Type 1 (ADH1) - Rachel Gafni
• The safety and efficacy of eneboparatide, a parathyroid hormone 1 receptor agonist, in adults with chronic hypoparathyroidism: a phase 3, randomized, placebo-controlled study (CALYPSO) - Maria Luisa Brandi
• Outcome of Phase-2 trial of Canvuparatide for Hypoparathyroidism - Michael Mannstadt

10.10 Aliya Khan: Trial outcomes and clinical experience with Palopegteriparatide (recorded presentation)

• Effect of age and NMN supplementation during rescue in vitro maturation on human oocyte meiotic architecture - Denise Lin
• Dissecting the molecular pathways of ovulation using ex vivo follicles  - Alexa C Mungur
• Inhibition of mtDNA replication by oocyte- specific deletion of Polg causes nuclear epigenetic alterations. - Ziyi Sha
• Early indicators of ovulation identified through remote monitoring in pigs - Sarah James
• Mitochondrial DNA replication reveals functional heterogeneity of mitochondrial nucleoids during oocyte growth - Manlin Xu
• The role of TIMM44 in premature ovarian insufficiency - Xuebi Cai
• Proteomic insights into the mechanisms driving oocyte quality in the context of hormonal stimulation and clinical IVM systems - Emily R Frost
• Anti-Mullerian hormone protects human ovarian follicles and stromal cells from immediate and sustained cyclophosphamide-induced damage in vitro - Roseanne Rosario

• PACT (Primary Aldosteronism Clinical Tool): A web-based clinical decision support tool for interpretation of the aldosterone-renin ratio - Kay Weng Choy
• Does continued antihypertensive therapy compromise adrenal vein sampling subtyping in primary aldosteronism?   - Xiaoxiao Song
• Investigating the 11-oxyandrogens and 21-deoxycortisol for therapeutic monitoring of congenital adrenal hyperplasia - Bronwyn G.A. Stuckey
• Outcomes and opportunities: evaluating an unselected cohort of patients with adrenal incidentaloma at a tertiary hospital in New Zealand   - Anthony Benfell

• Insights into sirtuin 1 as a potential regulator of spermatogonial stem cell function and chemotherapy resistance - Jess M Lyons

Award sponsored by: 

• Developing a high-resolution sperm morphology dataset for AI-driven bull fertility prediction  - Grace Donaldson
• Altered systemic inflammatory signalling in stallions with heat-susceptible subfertility: CRISP3 and IL-6/STAT3 as candidate drivers of seminal antioxidant loss - Narantsatsral Sandagdorj
• The role of sperm miRNAs in the paternal inheritance of diabetes and obesity development - Katharina Laurent
• Proteomic mapping of preconception environmental and endocrine stress signalling in the mouse caput epididymis - Jess E. Mulhall
• Epididymal epithelial cells undergo NLRP3 inflammasome-associated pyroptosis during inflammatory stimulation - Erick JR Silva
• A poorly characterised focal adhesion protein is required to maintain sperm structure and is essential for male fertility in mice - Gemma Stathatos
• TEX9 is essential for centriole to basal body maturation and thus sperm tail development and male fertility in the mouse - Maddison L Graffeo

Society award presentations & closing remarks from ESA, SRB & NZSE Presidents

• Cracking the FSH Code: A 25-year odyssey - Daniel Bernard

Co-Chairs: Aliya Khan & Romuald Mentaverri

• Upacicalcet: first in a new class of calcimimetic that targets the CaSR amino acid binding site - Takayuki Hamano
• Encaleret reveals PTH-independent regulation of renal calcium handling by the calcium-sensing receptor and demonstrates therapeutic potential in postsurgical hypoparathyroidism - Michael Collins
• Randomized Pilot Clinical Trial Testing Combined Therapy for Osteoporosis in Men with Low Bone Mass: Dual Activation of Calcium-Sensing Receptors (CASRs) and Parathyroid Hormone Receptors (PTHRs) - Dolores Shoback

Co-Chair: Sam Cheng

• The calcium-sensing receptor links polyamine metabolism with inflammatory and fibrotic responses in pulmonary fibrosis - Polina Yarova
• Targeting the CaSR in the treatment of pollution-driven obstructive airways disease - Daniela Riccardi
• Clinical course and functional characterization of anti-CaSR antibodies in autoimmune hypoparathyroidism - Hirofumi Horikoshi

• Beyond the Volcano Plot: Letting Biology Drive the Analysis of Isotope Tracing, Metabolomic, and Lipidomic Data - Andrew J Hoy
• Physiologically relevant in vitro and ex vivo culture techniques - Jeff Holst
• Spatial protein analyses: tips and suggestions - Jenny Gunton
• Patient-Derived Organoid Models for Precision Medicine in Gynaecological Diseases - Dongli Liu
• Imaging the tumour microenvironment: From matrix architecture to live cell dynamics - Brooke Pereira

3:35pm - General Discussion

• Interaction between calcium and L-tryptophan to modulate gut hormone secretion in health, obesity and type 2 diabetes - Javad Anjom-Shoae
• Treatment of secretory diarrhea with magnesium via activation of calcium-sensing receptors in intestinal epithelial cells - Onur Cil
• Deficiency in Gna11 impairs enamel mineralization by delaying ameloblast transition to the maturation stage in Familial Hypocalciuric Hypercalcemia type 2 - Franceska Kovaci
• Hypothalamic CaSR in the control of energy and skeletal metabolism - Kevin Murphy
• Ophthalmate tripeptide is a regulator of motor functions via the CaSR - Amal Alachkar

Co-Chair: Javad Anjom-Shoae

• Positive Allosteric Modulation of Human and Chicken Calcium-Sensing Receptors by CySSG and Caffeine - Fuminori Kawabata
• GWAS data and the hypothesis of hepatic glutathionergic regulation of serum calcium via a CaSR-mediated mechanism - Jeffrey L. Ram
• Evidence for autocrine activation of the calcium-sensing receptor by glutathione - Mahvash A Goolam

17:10: Prizes (posters, oral presentations); Travel Awards

17:25 Panel-led Discussion: key outcomes of CaSR-5 and future challenges of CaSR research
(Panel: Wenhan Chang, Ed Nemeth, Arthur Conigrave, Caroline Gorvin, Noriko Makita, Mike Collins, Maria Luisa Brandi, Raj Thakker)

17 45: Arthur Conigrave and Michael Mannstadt: Reflections on the future of the CaSR Symposium, Publication of Proceedings

18.10 Symposium ends