Male infertility affects millions of men worldwide, arising from various genetic, environmental, and unknown causes. My research program focuses on understanding how the male reproductive system is formed and functions to produce sperm capable of fertilisation. I investigate the cell biology and molecular mechanisms that underpin sperm development, maturation and function, and how the male reproductive system reacts to negative environmental and lifestyle factors. To do so, I use a variety of cell and animal models, including the generation of numerous mutant mouse and fly models. My research focus has recently expanded to consider how genetic and environmental factors may interact to exacerbate male infertility, which will provide insights of relevance to human health broadly.
In this presentation, I will provide an overview of my research journey, exciting findings and rewarding collaborations while working across four institutions in Australia and explore the opportunities and challenges I have faced.